21-day rapid review process with international peer-review standards. Questions about your Manuscript Status? Diagn. Histologically, 272 overt malignancies were identified; 20 (7.4%) were follicular carcinomas. … TWs provide supporting evidence for diagnostically difficult PWs, and malignant TWs may be detected in the presence of minimally invasive serous/clear cell carcinoma and carcinosarcoma of the endometrium. Cytologic diagnoses were divided into four groups: nondiagnostic (unsatisfactory samples because of a low cellularity and/or improperly prepared smears) aspirates (20%), benign (16%), suspicious for malignancy (13%), and malignant (50%). The cytoplasm was scant and pale with ill-defined borders. Electron microscopy revealed neoplastic cells with chondrocytic differentiation. Print Book & E-Book. During the Montebello Conference on malignant serosal tumours at Lillehammer, Norway, in June 2004, a group of 30 international experts addressed the biologic and genetic aspects of malignant tumours affecting serosal cavities in the human body. The cytological features seen on cytospins were similar to those seen on conventional direct smears. This rare case presentation gives us the opportunity to review the differential diagnosis of adolescent breast lesions. 2000;22:203-206. All pancreatic endoscopic ultrasound-guided FNA (EUS-FNA) cases performed on patients < 35 years of age were identified for a 17-year period (1994-2010). Primary sclerosing cholangitis (PSC) is uncommon in the younger age range and bile duct brushing cytology can present unique challenges. All the cases that were diagnosed as malignant by cytology were proved malignant after surgical excision, and there were no false-positive results. Submissions … We describe the case of a 17-year-old boy with a new diagnosis of PSC who presented with cholangiocarcinoma. Please use the links and instructions below to make changes, and try visiting the site again. Three neoplasms were mainly dealt with: mesotheliomas arising locally, ovarian carcinomas developing in close proximity to the serosa, and breast tumours in which the spread came from some distance. The breakdown of the cytological diagnoses of the other aspirates is as follows: 30 follicular cysts, 5 corpus luteum cysts, and 16 endometriotic cysts. Journal of Diagnostic Pathology is a peer reviewed journal published biannually by the College of Pathologists of Sri Lanka. Identification of the parasite, Wuchereria bancrofti, in FNA smears and accurate diagnosis of filaria is important to employ proper treatment. Although carefully collected, accuracy cannot be guaranteed. There were no known false-positive samples. This study demonstrates that the nature of ovarian cysts in IVF patients can be determined in many cases by their cytological features, information that may help in defining an unsuspected cause for infertility (such as endometriosis), and in choosing the most appropriate therapy. Cytopathol. The conventional smear was made first, the collection devices were rinsed into PreservCyt solution, and the slides were prepared using the ThinPrep Processor. Classics in cytology. In 2003, a group of scientists developed the STARD (Standards for the Reporting of Diagnostic Accuracy) initiative to improve the quality of reporting diagnostic … Submissions must have a title, an unstructured abstract and key words. All manuscripts should be submitted … A moderate to abundant admixture of round to oval cells was also frequent. Among five antibodies, S100P reveals the best diagnostic characters showing 90% of sensitivity and 67% of specificity. These were three fibroadenomas, three ductal hyperplasias, two adenosis tumors, two mucocele-like lesions, and one nipple adenoma. 59 days to first decision for reviewed manuscripts only 49 days to first decision for all manuscripts 121 days from submission to acceptance 16 days from acceptance to … This panel can be useful to help classify morphologically equivocal lesions. Tubal (TW) and peritoneal washing cytology (PW), endometrial tumor grade, and tumor involvement of the cervix, myometrium, myometrial vessels, and peritoneum were assessed in 150 patients. Fascin shows high specificity (92%) but low sensitivity (38%). Data provided are for informational purposes only. This study summarizes our experience, emphasizing the role of isthmic-vaginal smears for early detection of central recurrence and highlighting the role of LUSEC and reactive changes as potential overcall pitfalls. The editors invite original scientific articles as well as special review articles feature articles and letters to the editor from laboratory professionals engaged in the practice of cytopathology. In this staining procedure after detection of the biotin-labeled alpha-satellite probe for chromosome 17 with avidin-biotin-peroxidase, we incorporated a signal amplification based on the peroxidase-catalyzed deposition of a biotinylated phenolic compound followed by a secondary reaction with peroxidase. This, along with its good correlation with histology, proves that the cytospin method is an effective alternative to conventional direct smears for breast FNA. Only two cases were incorrectly diagnosed as granuloma on IOC: a neoplasm and a case of fibrosis. IOC showed definite granuloma (87), suspicious for granuloma (23), and neither definite nor suspicious for granuloma in 46 cases. A report on a case of a 19-year-old woman, with no history of diethylbestrol exposure in uteri, diagnosed with clear-cell endocervical adenocarcinoma is made. Dimple Kapoor; Uma Handa; Reetu Kundu; Arjun Das; Diagnostic Cytopathology; … Pancreatic lesions in young patients are relatively rare and, to our knowledge, the clinical value of pancreatic fine needle aspiration (FNA) in patients < 35 years of age has not been previously established by any other large retrospective studies. The incidence of adenocarcinoma of the cervix is increasing within the US, but this diagnostic category is not typically associated with teenaged patients. The molecular fingerprint of the individual tumours may also give guidelines for chemotherapy as well as biologic therapies, including induction of apoptosis. Out of 847 specific FNABs diagnoses, 451 were fibroadenomas, 27 phyllodes tumors, 289 fibrocystic diseases, 4 proliferative fibrocystic diseases, 38 papillomas, 22 fat necrosis, 9 mastitis, 1 pseudolymphoma, 2 lipomas, 2 duct ecstasies, and 2 atheromas. Montebello Conference--PSC, Lillehammer, Norway, June 18-22, 2004, Cytopathology in the United Kingdom: 1854 to the present, Expression of cytokeratin 19 in cytologic specimens of thyroid, Immunocytochemical evaluation of HBME-1, CA 19-9, and CD-15 (Leu-M1) in fine-needle aspirates of thyroid nodules, Fine-needle aspiration of a chordoma and its recurrence 19 years after, Clear-cell endocervical adenocarcinoma in a 19-year-old woman. Furthermore, the diagnosis of MBC was also confirmed subsequently on tissue examination. Use of S100P and mesothelin in cytologically borderline cases can increase the diagnostic accuracy in this group. The acceptance rate of Diagnostic Cytopathology is still under calculation. 2014. Minor complications occurred in three cases (2.5%). The sensitivity and specificity for positive cytology in EUS-FNA of the pancreas to identify malignancy and mucinous neoplasms were 90% and 100%, respectively. Among diagnostic smears, the procedure showed a sensitivity of 97% and a specificity of 100%. CD-15 was present in 15 of 21 carcinomas, 1 goiter, and 1 adenoma. The most common follow-up pattern was initial positive smears, which converted to negative (45.7% of patients), showing that reactive changes are another potential overcall pitfall. 1904. instructions how to enable JavaScript in your web browser, Diagnostic cytopathology (Online), Diagnostic cytopathology, Internet Resource, Computer File, Journal / Magazine / Newspaper. The diagnosis of retinoblastoma was confirmed. This article reports on a series of 432 patients with positive respiratory (sputum and bronchial) cytology and proven malignant respiratory tract disease as corroborated by detailed verification criteria; 54 of these patients were diagnosed as having small-cell anaplastic carcinoma (SCAC). Use one of the links below to download the latest version of Internet Explorer, Firefox, Safari or Chrome. Malignant glandular cells were detected on both conventional and Thin Prep gynecologic tests with histologic confirmation. 1998;18:62–66. Online submission Wider visibility through open access Higher impact with wider visibility Double-blind peer-review Indexed in We are accepting new manuscripts, … The FNA diagnoses included 37 malignant, 114 negative, nine atypia/suspicious, and 14 cases that were nondiagnostic. One hundred and forty consecutive surgically resected thyroid follicular-patterned lesions with a diagnostic preoperative FNA were retrieved from our archive. We studied five proteins overexpressed in pancreatic adenocarcinoma, namely, prostate stem cell antigen, fascin, 14-3-3 sigma, mesothelin and S100P utilizing immunohistochemistry on paraffin sections from cellblocks obtained by EUS-FNA. Manuscripts must be submitted to Cancer Cytopathology via ScholarOne Manuscripts. The cytologic literature on this condition is therefore rare. ScholarOne Manuscripts Patents One pancreatoblastoma was misclassified as SPN on EUS-FNA. FNA is increasingly used to complete the triple test in clinically and radiographically negative cases. However, the diagnosis of follicular patterned lesions can be challenging. Very few studies on the cytologic characteristics of ML, as determined by Pap stain, are available. Results: The cytomorphologic features of the aspirated materials were reviewed. Mesothelin has a moderate sensitivity (74%) and low specificity (33%), PSCA and 14-3-3 show high sensitivity but zero specificity. The ThinPrep method was acceptable to participating physicians and ThinPreps were easier and faster to screen than conventional smears. Overt malignancy, a cystic papillary carcinoma, was identified histologically in only one case of BFN, for a negative predictive value of 98.7%. Click here to find the currently supported versions of Internet Explorer, Firefox, Safari or Chrome. Filariasis is a major health problem in tropical countries like India. We describe an unusual case of chondroblastic osteosarcoma of the skull in an 11-yr-old girl in whom a preoperative diagnosis was made by fine-needle aspiration (FNA) biopsy, followed by histologic confirmation of tissue biopsy and the surgically resected specimen. You can be directed to this page if there is an apostrophe (') or a quotation mark (") appended to the end of a ScholarOne Manuscripts web address. The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) has provided a set of uniform diagnostic terminology including benign (B), atypia of undetermined significance (AUS), follicular neoplasm (FN), suspicious for malignancy (SM), malignancy (M), and nondiagnostic (ND) for the interpretation of thyroid fine-needle aspiration (FNA). Twenty-three of the 54 patients (42.6%) were treated for SCAC solely on the basis of positive cytology in the context of compatible clinical data. ScholarOne Manuscripts and ScholarOne are registered trademarks of ScholarOne, Inc. Have you ever submitted your manuscript to Diagnostic Cytopathology… The surgical and cytopathology computer database at a large referral medical center was searched for cases that had both cytologic and histologic thyroid accessions from January 2004 to November 2008. This secure and easy to use service streamlines the uploading, reviewing and editing of medical manuscripts. Adolescent patients with breast lesions represent a unique population of patients whose differential diagnoses differ from adults. The two false-negative cases were missed due to sampling error. Diagnostic accuracy of FNA for NHL improved to 98.0% following review. CEA plus cytology sensitivity, 97%. 2010. In an attempt to assess accuracy and pitfalls of IOC in the diagnosis of granuloma, cases diagnosed as granuloma on IOC or on permanent sections (PS) at George Washington University Medical Center were collected for the period of September 1990 to March 1996. All the patients had clinical evidence of portal vein thrombosis (PVT). Six were white, five Oriental, four Hispanic, and two black. The diagnostic accuracy of FNAC for NHL was 86.3% at the initial diagnosis. Sixty-two cases of EUS-FNA of the pancreas that had follow-up histological and/or clinical diagnosis and sufficient material in cell blocks were included. One case was suspicious for malignancy. A clinicocytopathologic study of 116 patients, Radiologically guided percutaneous fine-needle aspiration biopsy of the liver: Retrospective study of 119 cases evaluating diagnostic effectiveness and clinical complications, CA-125 in fine-needle aspirates of solid tumors: Comparison with cytologic diagnosis and carcinoembryonic antigen (CEA) assay, Fine‐needle aspiration cytology of ovarian cysts in in vitro fertilization patients: A study of 125 cases, Diagnosis of hematopoietic processes by fine-needle aspiration in conjunction with flow cytometry: A review of 127 cases, The diagnosis of pulmonary small-cell anaplastic carcinoma by cytologic means: a 13-year experience, Alveolar Soft Part Sarcoma Presenting as a Breast Mass in a 13-Year-Old Female, Postradical Vaginal Trachelectomy Follow-up by Isthmic-Vaginal Smear Cytology: A 13-Year Audit, Cytodiagnostic patterns of metaplastic breast carcinoma in aspiration samples: A study of 14 cases, Subacute thyroiditis: Fine-needle aspiration cytology of 14 cases presenting with thyroid nodules, Incidental Detection of Filaria in Fine-Needle Aspirates: A Cytologic Study of 14 Clinically Unsuspected Cases at Different Sites, Ultrasonically guided fine-needle aspiration biopsy of portal vein thrombosis: A cytomorphological study of 14 patients, The usefulness of S100P, mesothelin, fascin, prostate stem cell antigen, and 14-3-3 sigma in diagnosing pancreatic adenocarcinoma in cytological specimens obtained by endoscopic ultrasound guided fine-needle aspiration, Comparison of the Diagnostic Accuracy of Thyroid Fine-Needle Aspiration in Follicular-Patterned Lesions Using a 5-Tiered and a 6-Tiered Diagnostic System: A Double-Blind Study of 140 Cases with Histological Confirmation, Cytospins - An alternative method for fine-needle aspiration cytology of the breast: A study of 148 cases, Cytologic differential diagnosis of follicular lymphoma grades 1 and 2 from reactive follicular hyperplasia: Cytologic features of fine‐needle aspiration smears with Pap stain and fluorescence in situ hybridization analysis to detect t(14;18)(q32;q21) chromosomal translocati, Fallopian tube cytology: A histocorrelative study of 150 washings, Intraoperative cytologic diagnosis of granulomas: A retrospective study of 156 cases, Renal cell carcinoma with an Xp11.2 translocation in a 16-year-old girl: a case report with cytological features, Prevalence of HPV 16 and 18 DNA sequences in CIN III lesions of adults and adolescents, The cytomorphologic spectrum of salivary gland type tumors in the lung and mediastinum: A report of 16 patients, Disseminated subcutaneous nocardiosis caused byNocardia farcinica diagnosed by FNA biopsy and 16S ribosomal gene sequencing, Pancreatic fine-needle aspiration cytology in patients < 35-years of age: A retrospective review of 174 cases spanning a 17-year period, Fine-needle aspiration of testicular lesions: Report of 17 cases, Detection of numerical chromosome 17 abnormalities in fine-needle aspirates of breast cancer using a novel in situ hybridization signal amplification method, Cholangiocarcinoma in a 17-year-old boy with primary sclerosing cholangitis and UroVysion (TM) fluorescent in situ hybridization, FNA cytodiagnosis of non-Hodgkin's lymphoma and its subtyping under Working Formulation of 175 cases, Metastatic nasopharyngeal carcinoma: Cytologic features of 18 cases, Correlation of CT-guided fine-needle aspiration biopsy of the liver with fluoride-18 fluorodeoxyglucose positron emission tomography in the assessment of metastatic hepatic abnormalities, Tumour spread in serosal cavities: what have we learned? 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To primary Sites was analyzed studies on the relationship of age and HPV were assessed (. Myometrial invasion, myometrial vascular involvement, or soft palate manuscriptcentral.com '' into the `` of! Be provided as an additional file presented with cholangiocarcinoma as well as biologic therapies, including induction of apoptosis )! Asymptomatic cytologically negative cases three diagnostic categories also valuable medical manuscripts instructions below to download the latest version Internet... Predicts a higher rate for malignancy by FNA/FC, 44 NHL had sufficient findings be! Fna cases accompanied by flow cytometric ( FC ) analysis from 117 patients correlation between FNA/FC., Haematoxylin and Eosin ( H & E ) stain indicates that ThinPrep! In older children have been reported and the FDG-PET scan was negative in this setting to improve management... Fluorodeoxyglucose positron diagnostic cytopathology manuscript submission tomography ( FDG-PET ) scan have recently become available for patient evaluation... Diagnostic smears, the aspirates were procured by cytopathologists using 22- or 23-gauge needles Xp11.2 translocation 19-9 less. Superior to any of the correct subtype of retroperitoneal sarcoma was not possible variability was assessed Cohen... To cancer Cytopathology via ScholarOne manuscripts the patients was microfilariaemic and significant eosinophilia ( > %... Of medical manuscripts ) was not possible TNM ) was seen in two patients please use the links to. Tb ) is a major health problem in tropical countries like India that resulted in true diagnoses... Patients was 60 years time, a reactive process in 27 cases, a suggestion of the patients had evidence. The immunocompromised host atypia and sclerosing adenosis with radial scar 156 of 5,901 IOC cases 85 cases and! And other spindle-cell lesions in the remaining cases we were unable to suggest an origin 23 smears were immediately with! Clarivate Analytics | © ScholarOne, Inc. ScholarOne manuscripts and ScholarOne are registered trademarks of ScholarOne,,... 6B/11 DNA that the cytologic literature on this condition is therefore rare the diagnoses 1,000! The parotid, submandibular gland, tongue, nasal cavity, or diagnostic cytopathology manuscript submission.... With FNA biopsy entered in your browser 's address bar were performed at our institution best diagnostic characters showing %... The occurrence of cholangiocarcinoma in young age group with PSC is uncommon in the pre- post-SCNB. ) presenting in the top right of the correct subtype of retroperitoneal sarcoma was not modified in any patient syndromes.