CA Cancer J Clin. [Medline]. [Medline]. Prognostic value of resection of primary tumor in patients with stage IV colorectal cancer: retrospective analysis of two randomized studies and a review of the literature. Morikawa T, Kuchiba A, Lochhead P, et al. Douglas D. Clopidogrel Boosts Bleeding Risk After Polypectomy. [Medline]. [65]  Among the recommendations are the following: RAS mutational testing of colorectal carcinoma tissue should be performed for patients who are being considered for anti-EGFR therapy; this analysis must include KRAS and NRAS codons 12, 13 of exon 2; 59, 61 of exon 3; and 117 and 146 of exon 4 ("expanded" or "extended" RAS), BRAF V600 mutational analysis should be done in conjunction with deficient mismatch repair (dMMR)/microsatellite instability (MSI) testing for prognostic stratification, dMMR/MSI testing must be performed in all colorectal cancers for prognostic stratification and identification of Lynch syndrome patients (BRAF mutation testing is not needed for Lynch syndrome if there is no high MSI (MSI-H) with loss of MLH1). [Full Text]. 2017 Apr 25. Nelson R. Pembro Approved for 1st-Line Use in MSI-H/dMMR Colorectal Cancer. BMJ. [Medline]. Overall, FIT screening identified 80% of patients with colorectal cancer diagnosed within 1 year of testing. Br J Cancer. [Medline]. 27(5):663-71. 8th ed. [Medline]. Cook NR, Lee IM, Zhang SM, Moorthy MV, Buring JE. Lacy AM, Delgado S, Castells A, et al. N Engl J Med. Ann Oncol. Help make it a reality. 169(6):657-66. Lichtenstein GR, Loftus EV, Isaacs KL, Regueiro MD, Gerson LB, Sands BE. 2005 Dec 1. 106(6):1135-46. [Full Text]. 10(1):63-9. 2007 Jul 20. Zhang X, Smith-Warner SA, Chan AT, et al. At the American Cancer Society, we’re on a mission to free the world from cancer. [Medline]. Le DT, Uram JN, Wang H, Bartlett BR, Kemberling H, Eyring AD, et al. [Full Text]. Any one of these tests can be used for screening. Lancet. [Medline]. [Full Text]. [Medline]. June 3, 2013; Accessed: January 30, 2018. National Comprehensive Cancer Network (NCCN). [Medline]. J Clin Oncol. The Taskforce proposed the following revisions of the TN categorization for colon cancer [Guideline] Stoffel EM, Mangu PB, Gruber SB, Hamilton SR, Kalady MF, Lau MW, et al. Aspirin for the chemoprevention of colorectal adenomas: meta-analysis of the randomized trials. Br J Surg. 2009 Apr 2. Siegel RL, Miller KD, Jemal A. [Full Text]. Song M, Wu K, Meyerhardt JA, Ogino S, Wang M, Fuchs CS, et al. 34 (2):179-85. Ann Intern Med. [Full Text]. Cho E, Lee JE, Rimm EB, Fuchs CS, Giovannucci EL. doi: 10.1093/annonc/mdt354. 2003 Jul 17. [Medline]. 2004 Aug 15. FDA approves an oncology drug that targets a key genetic driver of cancer, rather than a specific type of tumor. 2016 Jan 10. 2009 Mar 15. Reduced risk of distant recurrence after adjuvant chemotherapy in patients with stage III colon cancer aged 75 years or older. 2015 Jun 25. House MG, Kemeny NE, Gonen M, et al. Talk to your health care provider about which tests might be good options for you, and to your insurance provider about your coverage. Tsoi KK, Pau CY, Wu WK, Chan FK, Griffiths S, Sung JJ. 29(25):3381-8. Gunderson LL, Jessup JM, Sargent DJ, Greene FL, Stewart AK. Ann Oncol. For capsule colonoscopy, the patient swallows a pill camera that acquires images as peristalsis propels it through the gastrointestinal tract. Table 1. Cancer screening in the United States, 2018: A review of current American Cancer Society guidelines and current issues in cancer screening. 2020 Oct;31(10):1291-1305. doi: 10.1016/j.annonc.2020.06.022. 2007 Dec 15. [Medline]. Available Every Minute of Every Day. 1988 Sep 1. [Full Text]. Van Cutsem E, Tabernero J, Lakomy R, Prenen H, Prausová J, Macarulla T, et al. Chustecka Z. Bevacizumab’s indication extended in colorectal cancer. There is, however, evidence that excess body weight, lack of exercise and alcohol intake are risk factors for colorectal cancer. [Full Text]. KRAS mutations, which are present in about 40% of colon adenocarcinomas, affect sensitivity to treatment with biologic agents directed against the epithelial growth factor receptor (EGFR). Brouquet A, Overman MJ, Kopetz S, et al. 2013 Aug 8. J Clin Oncol. Meester RGS, Mannalithara A, Lansdorp-Vogelaar I, Ladabaum U. However, some other professional medical organizations, such as the US Multi-Society Task Force on Colorectal Cancer (USMSTF), do put out such guidelines. [Medline]. [Medline]. [Full Text]. The guideline on localized colon cancer was released on October 1, 2020 by the European Society for Medical Oncology. J Clin Oncol. Randomized trial of laparoscopic-assisted resection of colorectal carcinoma: 3-year results of the UK MRC CLASICC Trial Group. Standard colectomies for adenocarcinoma of the colon. Baron JA, Barry EL, Mott LA, Rees JR, Sandler RS, et al. The American Cancer Society is a qualified 501(c)(3) tax-exempt organization. 28(23):3687-94. Stop using calcium and magnesium with oxaliplatin. KRAS Mutations and Sensitivity to Epidermal Growth Factor Receptor Inhibitors in Colorectal Cancer: Practical Application of Patient Selection. Boller AM, Nelson H. Colon and rectal cancer: laparoscopic or open?. [62]. NCCN Clinical Practice Guidelines in Oncology: Colon Cancer. [73] ) are as follows: A review of Surveillance, Epidemiology, and End Results (SEER) population-based data on colon cancer by the American Joint Committee on Cancer (AJCC) Hindgut Taskforce found the following: T1-2N2 cancers have a better prognosis than T3-4N2 cancers, T4bN1 and T4N2 cancers have a similar prognosis, T1-2N1, T2N0, and T3N0 cancers have a similar prognosis, T1-2N2a, T2N0, T3N0 (T1N2a), and T4aN0 (T2N2a) have a similar prognosis, Prognosis for T4a lesions is better than that of T4b by N category, The number of positive nodes affects prognosis. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. [Full Text]. [Medline]. 370(9604):2020-9. 2019 Oct 1. 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